Major advances in basic research of cutaneous melanoma have lead to novel treatment options that are making a difference for melanoma patients. However, multiple challenges lie ahead and further advances are necessary, particularly with respect to resistance to these novel therapies. Institut Curie, Gustave-Roussy, Hôpital Ambroise-Paré and ISTEM belong to the Université Paris-Saclay. This university has the unique opportunity to regroup high profile teams and centers focusing their interest on this disease. Bringing together basic, translational and clinical scientists who focus on melanoma for a one-day meeting is an opportunity to share ideas and to stimulate efficient interactions.