Genome instability is a hallmark of cancer cells but also a cause of genetic diseases in humans. Our understanding of the causal relationships between genome instability and the development of human diseases rely on our knowledge of the basic mechanisms of DNA and RNA metabolism, from the spatial genome organization to the chromatin landscape up to the regulation of genome expression during development or in response to genotoxic stress.
The dysfunctions of these basic mechanisms related to genome metabolism underlie human diseases including cancer, aging, neurological disorders and immune deficiency.
The main topics are:
The DNA damage response as anti-cancer therapeutic targets and tools for diagnostic/prognostic.
This international course has two objectives:
The educational objectives are:
Train students to the evaluation process by awarding themselves the poster price.
Genevieve ALMOUZNI - FR
Anabelle DECOTTIGNIES - BE
Ludovic DERIANO - FR
Fumiko ESASHI - UK
Michaela FONTENAY - FR
Olivier HYRIEN - FR
Massimo LOPES - CH
Enzo POIRIER - FR
Beatrice RONDINELLI - FR
Filippo ROSSELLI - FR
Eli ROTHENBERG - US
Dominique STOPPA-LYONNET - FR
Terence STRICK - FR
Angela TADDEI - FR
Stephan VAGNER - FR
Wei YANG - US
John DIFFLEY – UK
Helle ULRICH - DE
This list of speakers may still change
Chunlong Chen, unit UMR3244 « Dynamics of Genetic Information: fundamental bases and cancer (DIG-Cancer) », team leader « Replication program and genome instability », Institut Curie, Paris.
Valérie Borde, unit UMR3244 « Dynamics of Genetic Information: fundamental bases and cancer (DIG-Cancer) », team leader « Chromosome Dynamics and Recombination », Institut Curie, Paris.
Sarah Lambert, unit UMR3348 « Genome Integrity, RNA and Cancer », team leader « DNA Recombination, Replication and Genome Stability », Institut Curie, Orsay.
Raphaël Ceccaldi, unit U830 « Cancer, Heterogeneity, Instability and Plasticity - CHIP », team leader « Alternative DNA repair mechanisms in human cancers », Institut Curie, Paris.
Daniele Fachinetti, unit UMR 144 « Cell Biology and Cancer », team leader « Molecular Mechanisms of Chromosome Dynamics », Institut Curie, Paris.
Aura Carreira, CENTRO DE BIOLOGÍA MOLECULAR SEVERO OCHOA, Madrid.
Chunlong Chen, unit UMR3244 « Dynamics of Genetic Information: fundamental bases and cancer (DIG-Cancer) », team leader « Replication program and genome instability », Institut Curie, Paris.
Valérie Borde, unit UMR3244 « Dynamics of Genetic Information: fundamental bases and cancer (DIG-Cancer) », team leader « Chromosome Dynamics and Recombination », Institut Curie, Paris.
Sarah Lambert, unit UMR3348 « Genome Integrity, RNA and Cancer », team leader « DNA Recombination, Replication and Genome Stability », Institut Curie, Orsay.
Raphaël Ceccaldi, unit U830 « Cancer, Heterogeneity, Instability and Plasticity - CHIP », team leader « Alternative DNA repair mechanisms in human cancers », Institut Curie, Paris.
Daniele Fachinetti, unit UMR 144 « Cell Biology and Cancer », team leader « Molecular Mechanisms of Chromosome Dynamics », Institut Curie, Paris.
Aura Carreira, Centro de Biologia Molecular SEVERO OCHOA, Madrid.
Organization:
30 participants
Selection on CV and recommendation letter.
