2020
April 20th
April 24th
Vignette
International course

Genome Instability and Human Disease

Genome instability is a hallmark of cancer cells but also a cause of genetic diseases in humans. Our understanding of the causal relationships between genome instability and the development of human diseases rely on our knowledge of the basic mechanisms of DNA and RNA metabolism, from the spatial genome organization to the chromatin landscape up to the regulation of genome expression during development or in response to genotoxic stress. 

The dysfunctions of these basic mechanisms related to genome metabolism underlie human diseases including cancer, aging, neurological disorders and immune deficiency.

 

Organization: 

  • Seminars by experts in the field of the mechanisms that maintain genome stability to large scale approaches (molecular signature using NGS and proteomic). Highlight how a research continuum, from basic research to clinical and translational research, provides opportunities to solve human health issues.
  • Workshops: Carrier development, Scientific communication, Technological workshop, Poster session, “Elevator Pitch”, Students will chair session 
  • Poster prize
  • Curie Museum visit. 

 

The main topics are:

  • Basics mechanisms for maintaining genome stability (repair, replication, DNA damage signaling, spatial genome organization).
  • Dysfunction of these pathways in human diseases (cancer, aging, immunodeficiency).
  • Molecular signature of Genome Instability.

The DNA Damage Response as anti-cancer therapeutic targets and tools for diagnostic/prognostic.

Registration deadline
Apply now

Presentation

Objectives

This international course has two objectives:

  • Gain knowledge of mechanisms ensuring genome stability, from fundamental molecular pathways (DNA replication, repair, transcription, genome organization) up to large scale approaches (molecular signature using NGS and proteomic).
  • Highlight how a research continuum, from basic research to clinical and translational research, provides opportunities to solve human health issues.

The educational objectives are :

  • Encourage the students to speak. Students will ensure the moderator role and introduce speakers + elevator speech

Train students to the evaluation process by awarding themselves the poster price.

Personal work

  • Carrier development
  • Scientific communication
  • Technological workshop
  • Poster session
  • “Elevator Pitch”
  • Students will chair session 
  • Poster prize

Round table for carrier development 

Evaluation

Students will be evaluated based on the following activities:

  • Chairman/Chairwoman activities
  • Participation and scientific animation
  • Elevator Pitch

Practical information

Details

Genome instability is a hallmark of cancer cells but also a cause of genetic diseases in humans. Our understanding of the causal relationships between genome instability and the development of human diseases rely on our knowledge of the basic mechanisms of DNA and RNA metabolism, from the spatial genome organization to the chromatin landscape up to the regulation of genome expression during development or in response to genotoxic stress. 

The dysfunctions of these basic mechanisms related to genome metabolism underlie human diseases including cancer, aging, neurological disorders and immune deficiency.

Selection result
March 25, 2020
There is no registration fee for this course

No registration fees are requested

Location
Bâtiment de Biologie du développement (BDD)
Amphithéâtre du bâtiment de Biologie du développement (BDD), 26 rue d’ULM, 75005, Paris.

Max. number of

30 people

Participants

30

Selection criteria

Selection on CV and recommendation letter. 

Speakers

Speakers

Constance ALABERT - UK

Sergio de ALMEIDA - PT

Sebastian AMIGORENA - FR

Allison BARDIN - FR

Renata BASTO - FR

Pascale BERTRAND - FR

Erika BRUNET - FR

Aura CARREIRA - FR

Frederic CHEDIN - US

Laure CRABBE - FR

Françoise DANTZER - FR

Corinne DUPUIS - FR

Jessica DOWNS - UK

Daniele FACHINETTI - FR

Vincent GELI - FR

Karim LABIB - UK

Christophe LACHAUD - FR

Benoît PALANCADE - FR

Eva PETERMANN - UK

Sophie POLO - FR

Pablo RADICELLA - FR

Marc-Henri STERN - FR

Keynote speakers

Steve JACKSON - UK

Steve KOWALCZYKOWSKI - US

Lorraine SYMINGTON - US

Organisers

UMR 3348

UMR 3244

Scientific Committee

Aura Carreira, unité UMR3348  « Stress génotoxiques et cancer », chef d’équipe « Recombinaison Homologue et Cancer », Institut Curie, Orsay.

Chunlong Chen, unité UMR3344 « Dynamique de l’information génétique », chef d’équipe « Programme de Réplication et instabilité du génome », Institut Curie, Paris. 

Valérie Borde, unité UMR3344 « Dynamique de l’information génétique », chef d’équipe « Dynamique des chromosomes et recombinaison », Institut Curie, Paris. 

Sarah Lambert, unité UMR3348 « Stress génotoxiques et cancer », chef d’équipe « Recombinaison, Réplication et Stabilité des Génomes », Institut Curie, Orsay.

Organisation

  • UMR 3348 - Genotoxic Stress and Cancer