April 8th
April 12th
International course

Genetic Instability and Cancer

The aim is to describe the current knowledges in the fields of DNA replication, repair and recombination and its consequences on genetic instability and cancer.

Key to the proper inheritance of the genetic information, cells should duplicate their genome before mitosis and avoid mutagenesis. The course will describe the mechanisms and the regulations that ensure the maintenance of genetic information across cell generations. Focus will be put on initiation and completion of replication along the bulk chromosomes and at specific regions such as the telomeres ; the pathways of DNA repair and recombination ; the relationships linking replication stress to the formation of DNA damages ; the signalling of intrinsic and environmentally induced DNA damages ; the interferences with the transcriptional activity ; the variety of cellular responses to damages including the generation of chromosome rearrangements and oncogenesis. A large set of experimental methods involving genetic, molecular, cellular, biochemical approaches will be taught.

Course in English



The aim is to provide an updated overview  of the mechanisms and the regulation of the replication repair and recombination processes, the sources and the signalling of the damages, the cellular responses and the consequences in genome instability and oncogenesis. Today experimental approaches will be presented.

Personal Work

Single molecule visualization of an helicase activity by V. Croquette (ENS)

ECTS Information

This course is validated by UPMC - Paris VI University. It provides 3 ECTS or an equivalent of 30 hours.

Research themes

Practical Informations

Practical Informations

Master 2 or PhD students from France and abroad.

In advance, a scientific article chosen on the theme of the course will be attributed to the M2 students who will present and discuss orally this article and their expanded bibliographical analysis in a 20 minutes oral presentation +15 min discussion. This presentation can be evaluated by the organizers for university validation.

All participants should attend the 5 days course. Final acceptance of the PhD participants will require a signed engagement from their thesis supervisor attesting the student’s availability for the whole week.

The courses will be in English. The participants and speakers will meet every day during lunch time on site.

There is no registration fee for this course
Campus de l'Institut Curie, 75005 Paris, France



Michelle Debatisse
Alain Nicolas
Franck Toledo
Membres de l'unité IC/CNRS UMR3244/UPMC



  • UMR 3244 - Dynamics of Genetic Information: fundamental bases and cancer (DIG-Cancer)