Epigenetics

The aim of this course is to provide an overview of epigenetic mechanisms and their links to gene expression and chromatin dynamics in different systems. The diverse functions of the nucleus involving the genome and its organization will be discussed with an emphasis on technological limits and the new experimental approaches being developed today. Links between the disruption of nuclear functions and the development of human pathologies will be discussed. This year, focus will be on reprogramming aspects during development and in disease with a special emphasis on cancer.