The course presents the current knowledge in neural crest and melanocytes development (cell biology, transcriptomics, imaging...) as well as how melanocytes undergo tumor progression in adults. It ends with presentation of the most up-to-date therapeutical strategies.
In humans, pigment cells comprise the neural crest-derived melanocytes and the pigmented retina cells. Tumor transformation in both cell types results in cutaneous or uveal melanomas, two usually aggressive and hard-to-treat tumour types.
This course will address the development, the differentiation and the migratory behaviour of melanocytes in embryos and melanoma formation and metastasis in adults. Focus will be made on cellular and molecular mechanisms controlling these processes. The course will then address how advanced imaging technologies, systems biology, and in vivo approaches have progressed in melanoma understanding in the last few years. Finally, some directions for therapeutic approaches will be developped.
To discuss the big questions in the field of Development and Cancer. To provide an up-to-date landscape on melanocyte biology, for master and doctoral students as well as for researchers and clinicians.
Topics :
Pigment cell development: signals, differentiation and migration
Cell migrations in vivo, in embryos and cancer
Cutaneous and uveal melanomas
Medulloblastoma biology
High throughput technologies and imaging for tumor analysis
Melanoma and therapies.
Anne-Hélène Monsoro-Burq, (Institut Curie and Université Paris Sud)
Simon Saule (Institut Curie and Université Paris Sud)
Patrick Pla (Institut Curie and Université Paris Sud)
Anne-Céline Derrien (Institut Curie)
Anne-Hélène Monsoro-Burq, (Institut Curie and Université Paris Sud)
Simon Saule (Institut Curie and Université Paris Sud)
Patrick Pla (Institut Curie and Université Paris Sud)
Anne-Céline Derrien (Institut Curie)
