November 3rd
November 9th
International course

Multiscale integration in Biological Systems

2 edition

Physical description of biological systems, from the single molecule to organisms.

One of the fundamental issues in biology is the understanding of the relationship between the multiple spatial and temporal scales observed in a biological system. From molecules to a cellular function, from a collection of cells to an organism, or from individuals to a population, the complex interactions between singular elements can give rise to “emergent” properties at the ensemble level. To what extent can the spatial and temporal order seen at the system level be explained by subscale properties?

During this course, most seminars were filmed.

Course in English



The course will give an overview of modern physical tools that have been developed to address the issue of scale integration (mornings) and will show how these tools can be applied to specific biological systems (afternoons).

University credits (ECTS)

(The course will provide 10 ECTS at some doctoral schools in Paris, e.g. ED PIF and ED FDV). Students or researchers can also audit the course without receiving credit.

Research themes

Student work


Practical information



- Statistical physics of out of equilibrium systems / Information theory, inference techniques.
- Non-linear physics, criticality / bistability, switches, oscillations, signal amplification.
- self-organization, collective phenomenon, phase transitions / pattern formation, flocks, cellular
  architecture, development.
- evolution, cooperativity and competition / population genetics, evolutionary approach of cancer.

There is no registration fee for this course

All lunches will be provided by Institut Curie. Participants’ home laboratories are responsible for paying travel and lodging. Institut Curie will pre-booked hotel rooms at preferential rates. A few fellowships will be available upon request and granted to the best presentations.


Institut Curie - Paris



Rosalind ALLEN (UK), Robert AUSTIN (USA), Nathalie BALABAN (IS), Ginestra BIANCONI (UK), Simona COCCO (FR), Mathieu COPPEY (FR), Marileen DOGTEROM (NL), Hervé ISAMBERT (FR), Jean-François JOANNY (FR), Mustafa KHAMMASH (CH), Marc LEFRANC (FR), James MARSHALL (UK), Leonid MIRNY (USA), Thierry MORA (FR), Stéphanie PALMER (USA), Leïla PERIÉ (FR), Félix RITORT (SP), Olivier RIVOIRE (FR), Udo SEIFERT (DE), Massimo VERGASSOLA (USA).


M. Coppey, M. Dahan, H. Isambert, P. Martin, P. Nghe, P. Sens, P. Silberzan, A. Walczak

Scientific Committee

M. Coppey, M. Dahan, H. Isambert, P. Martin, P. Nghe, P. Sens, P. Silberzan, A. Walczak

Sponsored by


  • Training Unit - Institut Curie