February 14th
February 18th
International course

Genome Instability and Human Disease

Genome instability is a hallmark of cancer cells but also a cause of genetic diseases in humans. Our understanding of the causal relationships between genome instability and the development of human diseases rely on our knowledge of the basic mechanisms of DNA and RNA metabolism, from the spatial genome organization to the chromatin landscape up to the regulation of genome expression during development or in response to genotoxic stress.

The dysfunctions of these basic mechanisms related to genome metabolism underlie human diseases including cancer, aging, neurological disorders and immune deficiency.

This edition will take place in real-time virtual format (CET, Paris time). Participation is free of charge and participants are selected by the scientific committee (check below the documents needed for application).

Activities (13 PM - 19 PM CET):

  • Seminars by experts in the field of the mechanisms that maintain genome stability to large scale approaches (molecular signature using NGS and proteomic). Highlight how a research continuum, from basic research to clinical and translational research, provides opportunities to solve human health issues.
  • Workshops: Carrier development, Scientific communication, Technological workshop, Poster session, “Elevator Pitch”, Students will chair session
  • Poster prize
  • Online Networking events

The main topics are:

  • Basics mechanisms for maintaining genome stability (repair, replication, DNA damage signaling, spatial genome organization).
  • Dysfunction of these pathways in human diseases (cancer, aging, immunodeficiency).
  • Molecular signature of Genome Instability.

The DNA Damage Response as anti-cancer therapeutic targets and tools for diagnostic/prognostic.

This course in sponsored by Bionano Genomics.

Course in English
Registration deadline



This international course has two objectives:

  • Gain knowledge of mechanisms ensuring genome stability, from fundamental molecular pathways (DNA replication, repair, transcription, genome organization) up to large scale approaches (molecular signature using NGS and proteomic).
  • Highlight how a research continuum, from basic research to clinical and translational research, provides opportunities to solve human health issues.

The educational objectives are :

  • Encourage the students to speak. Students will ensure the moderator role and introduce speakers + elevator speech

Train students to the evaluation process by awarding themselves the poster prize.

Discussion & Workshops

Round table for career development 

Personal Work

  • Chairman/Chairwoman activities
  • Participation and scientific animation
  • Elevator Pitch & Poster

ECTS Information


Practical Informations

Practical Informations


Selection result
January 27, 2022
There is no registration fee for this course
Institut Curie - Online
En ligne

Maximum Number of Participants

40 people

Number of Participants

40 participants

Selection Criteria

Selection on CV and recommendation letter.



Karim Labib, University of Dundee, UK.

Eva Petermann, University of Birmingham, UK

Allison Bardin, Institut Curie, FR

Juan Mendez, CNIO, ES

Renata Basto, Institut Curie FR.

Marc-Henri Stern, Institut Curie, FR

Manuel Rodrigues, Institut Curie, FR

Joanna Loizou, Institute of Cancer Research, Vienna

Constance Alabert, University of Dundee, UK.

Sophie Polo, Université Paris Diderot, FR

Daniele Fachinetti, Institut Curie, FR

Vincent Géli, CRCM, FR

Claus Azzalin, Institut De médecine Moléculaire, PT

Domenico Libri, IJM, FR

Sebastian Amigorena, Institut Curie, FR

Erika Brunet, Institut Imagine, FR

Christophe Lachaud, CRCM, FR

Jean Soulier, Hopital Saint-Louis, FR

Pablo Radicella, CEA, FR 

Keynote speakers

This list of speakers may still change

Scientific Committee

Aura Carreira, Genome Instability and Cancer Predisposition" team leader, Severo Ochoa Centre for Molecular Biology (CBMSO), Madrid, Spain.

Chunlong Chen, UMR3244 Unit, "Dynamics of Genetic Information", "Replication program and genome instability" team leader, Institut Curie, Paris.

Valérie Borde, UMR3244 Unit "Dynamics of Genetic Information", "Chromosome dynamics and recombination" team leader, Institut Curie, Paris.

Sarah Lambert, UMR3348 Unit "Genome integrity, RNA and Cancer", "DNA Recombination, Replication and Genome Stability" team leader, Institut Curie, Orsay.

Raphaël Ceccaldi, U830 Unit, "Cancer, Heterogeneity, Instability and Plasticity (CHIP)", "Alternative DNA repair in cancer" team leader, Institut Curie, Paris.


  • UMR 3348 - Genome Integrity, RNA and Cancer