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04/17/2019PhD Grant for Mds & PharmDs
04/17/2019Computational Systems Biology of Cancer - 2nd edition
The course presents the current knowledge in neural crest and melanocytes development (cell biology, transcriptomics, imaging...) as well as how melanocytes undergo tumor progression in adults. It ends with presentation of the most up-to-date therapeutical strategies.
To discuss the big questions in the field of Development and Cancer. To provide an up-to-date landscape on melanocyte biology, for master and doctoral students as well as for researchers and clinicians.
In humans, pigment cells comprise the neural crest-derived melanocytes and the pigmented retina cells. Tumor transformation in both cell types results in cutaneous or uveal melanomas, two usually aggressive and hard-to-treat tumour types.
This course will address the development, the differentiation and the migratory behaviour of melanocytes in embryos and melanoma formation and metastasis in adults. Focus will be made on cellular and molecular mechanisms controlling these processes. The course will then address how advanced imaging technologies, systems biology, and in vivo approaches have progressed in melanoma understanding in the last few years. Finally, some directions for therapeutic approaches will be developped.
In the practical part of this course, the notions developped in the seminars and courses will be illustrated by in vivo manipulations in embryos and in vitro cellular manipulation, both followed by advanced imaging analysis. An opening will be made on other cancers that have similarities with melanoma as medulloblastoma and glioblastoma.
Pigment cell development: signals, differentiation and migration
Cell migrations in vivo, in embryos and cancer
Cutaneous and uveal melanomas
Medulloblastoma and glioblastoma biology
High throughput technologies and imaging for tumor analysis
Melanoma and therapies.
Master 2 students, graduate students and postdoctoral fellows with a scientific background are invited to apply to the course. Researchers, engineers and clinicians are welcome as well. Seminars and talks will be in English. The practical course is open to Paris-Sud students and students registered in another French university.
Cette liste d'intervenants n'est pas définitive
Anne-Hélène Monsoro-Burq, (Institut Curie et Université Paris Sud),
Simon Saule (Institut Curie et Université Paris Sud),
Patrick Pla (Institut Curie et Université Paris Sud),
Caroline Borday (Institut Curie et Université Paris Sud),
Frédéric Coquelle (Université Paris Sud),
Laurence Méry (Institut Curie et Université Paris Sud)