2014
December 8th
December 19th
Vignette
International course

Inter-Individual variability of radiation-sensibility

Mechanisms and Biomarkers

The course will present the current knowledge on cellular and molecular responses to radiation exposure and how this can be exploited to identify biomarkers for use in molecular epidemiology studies.

During the first week, we will review the molecular consequences of low dose and dose rate exposures to ionising radiation from the generation of oxidative stress and damage at the macromolecular level to long term consequences such as  increased cancer risk, with the over-arching theme of individual susceptibility. How mechanistic knowledge can be integrated into molecular epidemiological studies and used to assess individual variation in susceptibility will be presented. In the second week students will participate in laboratory sessions on DNA/RNA extraction and genotyping techniques, the quantification of DNA and protein adducts, DNA repair activity and cell senescence using Fluorescent Activated Cell Sorting (FACS) and immunofluorescence.

Course in English

Presentation

Personal work

Extraction DNA and RNA, Genotyping, DNA Repair Assays, DNA and Protein Adducts.

Practical information

There is no registration fee for this course
Location
December 8 - 12, 2014: Lecture sessions held at Institut Curie, Paris
December 15 - 19, 2014: Practical sessions at CEA, near Paris

Participants

Applications can be made to attend either just the first week of lectures or for both weeks. No applications for just the second week will be considered.

Speakers

Organisers

Janet Hall
Sylvie Chevillard
François Leteurtre

With

Organisation

  • Training Unit - Institut Curie