2012
April 2nd
April 6th
Vignette
International course

DNA Replication, Genetic instability and Cancer

The aim is to describe the current knowledges in the fields of DNA replication, repair and recombination and its consequences in genetic instability and cancer.

Key to the proper inheritance of the genetic information, cells should duplicate their genome before mitosis and avoid mutagenesis. The course will describe the mechanisms and the regulations that ensure the maintenance of genetic information across cell generations. Focus will be put on initiation and completion of replication along the bulk chromosomes and at specific regions such as the telomeres ; the pathways of DNA repair and recombination ; the relationships linking replication stress to the formation of DNA damages ; the signalling of intrinsic and environmentally induced DNA damages ; the interferences with the transcriptional activity ; the variety of cellular responses to damages including the generation of chromosome rearrangements and oncogenesis. A large set of experimental methods involving genetic, molecular, cellular, biochemical approaches will be taught.

Course in English
3 ECTS

Presentation

Objectives

To provide an updated overview  of the mechanisms and the regulation of the replication repair and recombination processes, the sources and the signalling of the damages, the cellular responses and the consequences in genome instability and oncogenesis. Today experimental approaches will be presented.

Personal work

Single molecule visualization of an helicase activity by V. Croquette (ENS)

University credits (ECTS)

This course is validated by UPMC - Paris VI University. It provides 3 ECTS or an equivalent of 30 hours.

Practical information

There is no registration fee for this course
Location
Amphithéâtre Pierre et Marie Curie, 11 rue Pierre et Marie Curie, 75005 Paris, France

Speakers

Organisers

Alain Nicolas
Franck Toledo
Michelle Debatisse
Arturo Londono-Vallejo
Bernard Malfoy
Antonin Morillon
Membres de l’Unité IC/CNRS UMR3244/UPMC

Organisation

  • Training Unit - Institut Curie